• IDS 2020

    BEIJING CHINA APRIL 22-26

  • IDS 2020

    BEIJING CHINA APRIL 22-26

  • IDS 2020

    BEIJING CHINA APRIL 22-26

  • IDS 2020

    BEIJING CHINA APRIL 22-26

  • IDS 2020

    BEIJING CHINA APRIL 22-26

  • IDS 2020

    BEIJING CHINA APRIL 22-26

Program

17th IDS Congress Preliminary Agenda

Wednesday 14 October2020

8:30-8:40

Opening Ceremony: AnetteZiegler (Germany)& ZhiguangZhou (China)

8:40-9:20

Franco Bottazzo Lecture

Ake Lernmark (Sweden)40’

Chairs

Ezio Bonifacio (Germany)

Zhiguang Zhou (China)

9:20-11:20

Session 1Genetic Risk and Heterogeneity of T1D

Key Note Lecture Steve Rich (USA)30’

Advances in the Genetic Basis of Type 1 Diabetes and Application to Population Screening

Chairs :AG Ziegler (Germany) Z Zhou (China)

Speakers:(20’ each)

William Hagopian (USA): Applying Combined Risk Scores using Genetics, Family History and Islet Autoantibodies in Pediatric Population Screening and Selection for Prevention Trials

Tao Yang (China)

Andrea Steck (USA): Heterogeneity and Prediction of T1D

Panel Discussion 30’

11:20-12:30

Antibody Workshop IASP

Speakers:

Peter Achenbach

William Winter

Vito Lampasona

Michael Schlosser

David Pittman

Discussion 10’

12:30-13:00

Lunch

13:00-15:00

Session 2 Epigenetics and Transcriptomics of T1D

Key Note Lecture:David Leslie (UK) 30’

Epigenetics of T1D: Epiphany or Epiphenomenon?

Chairs :

Carani Sanjeevi (Sweden) Ezio Bonifacio (Germany)

Speakers:(20’ each)

Cong-Yi Wang (China): The implication of epigenetic factors in the initiation and progression of type 1 diabetes

Ranjeny Thomas (Queensland, Australia): Identification and therapeutic regulation of autoantigen-specific responses in pediatric type 1 diabetes)

Riitta Lahesmaa (Finland): Early detection of immune cell signatures in children developing beta-cell autoimmunity

Panel Discussion 30’

15:00-15:20

Coffee break

15:20-17:00

Session 3Novel Techniques for Antibody Detection

Chairs

Eddie James (USA) Linong Ji (China)

Speakers (20 min each)

Liping Yu (USA): Application of Multiplex ECL Assay in General population Screening for the risk of Type 1 Diabetes

Peter Achenbach (Germany)

Ahuva Nissim (UK):Oxidative post-translationally modified insulin as neoepitope in type 1 diabetes: prediction and diagnosis

Yang Xiao (China)

Panel Discussion 20’

17:00-18:00

Abstract Selected Flash Presentations

Chairs

Alice Long (USA) Susan Wong (UK)

Topics

Antigen Specific T cell responses

Immunological Tolerance

Innate immune pathways

Pathways to beta cell failure and death

18:00-19:00

Poster

Thursday 15 October 2020

8:30-10:30

Session 4 Update from Our Networks: TEDDY

Session Chair: Steve Rich (USA)

Presenters (30’each)

Anette Ziegler (Helmholtz Zentrum München, Germany): Hierarchical order of autoantibody spreading and progression to type 1 diabetes

Jill Norris(University of Colorado, USA): Nutrient exposures and risk of islet autoimmunity and type 1 diabetes

Marian Rewers (Barbara Davis Center for Diabetes, USA): Prospective infections and virome analyses in young children at increased genetic risk for type 1 diabetes

Discussion (30 min) led by Peter Coleman (Australia) Kathleen Gillespie (UK)

10:30-12:30

Session 5 Beta cell in Health and Disease

Key Note Lecture

Tao Xu (China ) 30’

Chairs

Bill Hagopian (USA) Bart Roep (USA)

Speakers (20’each)

Stephan Speier(Germany): In Situ Analysis of Human Islet Pathophysiology in T1D

Teresa Mastracci (USA)

Helen Thomas (Australia): The influence of cytokines and JAK inhibitors on expansion of antigen-specific T cells

Panel Discussion30’

12:30-13:00

Lunch

13:00-14:30

Session 6Characterization of autoimmune responses in tissues from organ donors: nPOD

Chair:Alberto Pugliese

Speakers (20’each):

Alberto Pugliese: nPOD Update/introduction

Todd Brusko:Analysis of T and B cell receptor, and RNA profiles, in immune cells from pancreas and lymphoid tissues from nPOD donors with and without T1D

Maki Nakayama: Antigen specificity and phenotypes of islet infiltrating T and B cells

General Discussion(30’): Led by Alberto Pugliese, Ezio Bonifacio, Todd Brusko, Maki Nakayama

14:30-14:50

Coffee break

14:50-15:50

Session 7Ballon Debate

Chairs

Noel Morgan (UK)

Carmella Evans-Molina (USA)

Persistent beta cells are:

Dead (effectively): Marcela Brissova (USA)

Stunned: Emily Sims (USA)

Sleeping:Richard oram (UK)

Differentiated: TeresaCalvo(Germany)

15:50-17:00


(10 min each:8 min talk plus 2 min Q & A)

Abstract SelectedShort Talks

Chairs

Tim Tree (UK)

Topics

Genetic and environmental influences on T1D

Islet Pathology

Therapeutics and clinical trials

17:00-18:00

Posters

18:30-20:30

Welcome Banquet

Friday 16 October 2020

8:30-10:20

Session 8Gut Microbiota in T1D

Chairs

Li Wen (USA) Guang Ning (China)

Speakers

Emma Hamilton-Williams(Australia) (30’)

Michael Knip (U Helsinki, Finland)(30’): Can the T1D Risk Be Modulated Through the Intestinal Microbiome?

Yu Liu (China) (20’)

Panel Discussion 30’ Bart Roep as a discussant with 3 slides

10:20-11:00

George Eisenbarth Lecture(40’)

Kevan Herold (USA)

Chairs

AG Ziegler (Germany)

MarianRewers (USA)

11:00-12:00

Session 9 Immunometabolism

Chairs

AG Ziegler (Germany)Fang Hu (China)

Speakers (20’ each)

Aimin Xu (China): Neutrophil-macrophage crosstalk in autoimmune diabetes

Agnes Lehuen (INSERM, U Paris, France): MAIT cells at the crossroad between microbiota, inflammation and metabolism

Panel Discussion 20’

12:00-13:00

Lunch

13:00-15:00

Session 10Adult-Onset Autoimmune Diabetes

Chairs

David Leslie (UK), Toshiaki Hanafusa (Japan), Zhiguang Zhou (China)

Speakers (20’ each)

Xia Li (China)

Tiina Tuomi (Finland)

Paolo Pozzilli (Italy): Clinical Practice Guideline recommendations for LADA treatment.

Panel Discussion30’

15:00-15:20

Coffee break

15:20-16:20

Session 11 Debate

Chairs

Peter Coleman (Australia) Marian Rewers (USA)

This House believes that:

There is only Type 1 diabetes Angus Jones (UK)

Type 1 diabetes can interface with Type 2 diabetes Mark Atkinson (USA)

16:20-17:00

Abstract Selected Flash Presentations

Chairs

Zhengqi Liu (USA)

Yufei Xiang (China/USA)

Topics

Autoantibody responses

Immune monitoring and biomarkers

Islet Immune interactions

17:00-20:00

City Tour

Saturday 17 October 2020

8:30-10:20

Session 12INNODIA - Updates from Networks Novel Clinical treatment

Chair: Chantal Mathieu, Coordinator of INNODIA, KU Leuven

Introduction to INNODIA: a greater plan(10min)

Speakers (20 min each, 5 min Q&A)

Francesco Dotta, UNISI: Dialogue between the immune system and the beta-cell

Mark Peakman, Sanofi: Multiomics analysis for biomarker discovery in T1D

David Dunger, UCAM and Anke Schulte, Sanofi: Novel pathways of clinical intervention in T1D (INNODIA Masterprotocol)

Discussion (30 min) led by Jay Skyler (USA) Matthias von Herrath (USA)

10:20-12:20

Session 13 Autoimmunity: Advances in Immunology

Key Note Lecture

Chen Dong(China) 30’ : CD4+ T cells in autoimmunity

Chairs

Dirk Homann (Germany)Z Zhou (China)

Speakers (20’ each)

Tetsuro Kobayashi(Japan): Distinct pathological changes of the pancreas in slowly progressive type 1 (insulin-dependent) diabetes

Abdu Hamad(USA)

Lucienne Chatenoud (France): Precision medicine in autoimmune diabetes : CD3 antibody immunotherapy, genetics and environment

Panel Discussion30’

12:20-13:20

T cell Workshop & Lunch

Eddie James

13:20-15:10

Session 14T and B lymphocytes in T1D

Chairs

Mark Peakman (UK),Susan Wong (UK)

Speakers (30’ each)

Roberto Mallone (France):βeauty is in the eye of the T-cell beholder

Susan Wong (UK): Beyond autoantibodies in type 1 diabetes - what role has the B cell?

Peggy Kendall (USA): Targeting anti-insulin B cells in T1D

Panel Discussion 20’

15:10-15:30

Coffee break

15:30-16:50

Session 15 Lessons from Other Autoimmune Diseases

Chairs:Li Wen (USA), Yongsoo Park (Korea)

Speakers (20’ each)

Zhanguo Li (Peking U, China)

Johnny Ludvigsson (Sweden)

Qianjin Lu (CSU, China)

Panel Discussion 20’

16:50-18:20

Session 16 Update from Networks Novel Clinical Treatment--TrialNet

Chairs:Kevan Herold

Speakers (20’ each)

Peter Gottlieb (USA)

Emily Sims (USA)

Alice Long (USA)

Discussion (30 minutes) led by Discussants Tom Kay (Australia) Lucienne Chatenoud(France)

Sunday 18 October 2020

8:30-10:30

Session 17 Islet Transplantation & Stem Cell Therapy

Chairs

Tom Kay (Australia) Shounan Yi (Australia)

Speakers (20’ each)

Philip O’Connell (Australia): Can a drug free immunosuppressive protocol be achieved for human islet transplantation

Qizhi Tang (USA): Islet-infiltrating Tregs in autoimmune diabetes and islet transplantation

Akihisa Imagawa (Japan): Usefulness of patient-derived iPS cells in fulminant type 1 diabetes

Hongkui Deng (China)(30’)

Panel Discussion 30’

10:30-11:50

Session 18 Immune Therapy

Chairs J Skyler (USA) Len Harrison (Australia)

Speakers (30’ each)

Colin Dayan (UK): JDRF TOMI and the way forward in beta cell preservation in T1D

David Rawlings (USA): Gene editing to generation engineered regulatory T cells for treatment of autoimmune disorders including T1D

Panel Discussion 20’

11:50-12:00

Conclusion

AG Ziegler (Germany)

Zhiguang Zhou (China)


Departure